Publications

Google Scholar Citations

Bjedov I, Cochemé HM, Foley A, Wieser D, Woodling NS, Castillo-Quan JI, Norvaisas P, Lujan C, Regan JC, Toivonen JM, Murphy MP, Thornton J, Kinghorn KJ, Neufeld TP, Cabreiro F, Partridge L. Fine-tuning autophagy maximises lifespan and is associated with changes in mitochondrial gene expression in Drosophila. PLoS Genet 2020; 16: e1009083.

Stead ER*, Castillo-Quan JI*, Miguel VEM, Lujan C, Ketteler R, Kinghorn KJ, Bjedov I. Agephagy – Adapting Autophagy for Health During Aging. Front Cell Dev Biol 2019; 7: 308. *Joint 1st authors.

Cochemé HM, Bjedov I, Grönke S, Menger KE, James AM, Castillo-Quan JI, Foley A, Lennicke C, Buricova M, Adcott J, Cabreiro F, Murphy MP, Partridge L. Enhancing autophagy by redox regulation extends lifespan in Drosophila. BioRxiv 2019; 790378.

Castillo-Quan JI, Tain LS, Kinghorn KJ, Li L, Grönke S, Hinze Y, Blackwell TK, Bjedov I, Partridge L. A triple drug combination targeting components of the nutrient-sensing network maximizes longevity. Proc Natl Acad Sci USA 2019; 116: 20817-20819.

Ewald CY, Castillo-Quan JI, Blackwell TK. Untangling Longevity, Dauer, and Healthspan in Caenorhabditis elegans Insulin/IGF-1-Signalling. Gerontology 2018; 64: 96-104.

Kinghorn KJ, Asghari AM, Castillo-Quan JI. The emerging role of autophagic-lysosomal dysfunction in Gaucher disease and Parkinson’s disease. Neural Regen Res 2017; 12: 380-384.

Kerr F, Sofola-Adesakin O, Ivanov DK, Gatliff J, Gomez Perez-Nievas B, Bertrand HC, Martinez P, Callard R, Snoeren I, Cochemé HM, Adcott J, Khericha M, Castillo-Quan JI, Wells G, Noble W, Thornton J, Partridge L. Direct Keap1-Nrf2 disruption as a potential therapeutic target for Alzheimer’s disease. PLoS Genet 2017; 13: e1006593.

Castillo-Quan JI, Blackwell TK. Metformin: Restraining Nucleocytoplasmic Shuttling to Fight Cancer and Aging. Cell 2016; 167: 1670-1671.

Kinghorn KJ, Grönke S, Castillo-Quan JI, Li L, Woodling NS, Sirka E, Gegg M, Hardy J, Partridge L. A novel model of GBA1-associated Parkinson’s disease implicates autophagy. J Neurol Neurosurg Psychiatry 2016; 87: e1

Kinghorn KJ, Grönke S, Castillo-Quan JI, Woodling NS, Li L, Sirka E, Gegg M, Mills K, Hardy J, Bjedov I, Partridge L. A Drosophila Model of Neuronopathic Gaucher Disease Demonstrates Lysosomal-Autophagic Defects and Altered mTOR Signalling and Is Functionally Rescued by Rapamycin. J Neurosci 2016; 36: 11654-11670.

Kinghorn KJ, Castillo-Quan JI, Li L, Bhatia KP, Abramov AY, Hardy J, Partridge L. Reply: Glial mitochondropathy in infantile neuroaxonal dystrophy: pathophysiological and therapeutic implications. Brain 2016; 139: e68.

Castillo-Quan JI, Li L, Kinghorn KJ, Ivanov DK, Tain LS, Slack C, Kerr F, Nespital T, Thornton J, Hardy J, Bjedov I, Partridge L. Lithium promotes longevity via GSK3/NRF2-mediated hormesis. Cell Rep 2016, 19: 638-50. (Cover Article)

Kinghorn KJ, Castillo-Quan JI. Mitochondrial dysfunction and defects in lipid homeostasis as therapeutic targets in neurodegeneration with brain iron accumulation. Rare Dis 2016; 4: e1128616.

Castillo-Quan JI, Kinghorn KJ, Bjedov I. Genetics and pharmacology of longevity: the road to therapeutics for healthy aging. Adv Genet 2015; 90: 1-101

Kinghorn KJ, Castillo-Quan JI, Bartolome F, Angelova PR, Li L, Pope S, Cochemé HM, Khan S, Asghari S, Bhatia KP, Hardy J, Abramov AY, Partridge L. Loss of PLA2G6 leads to elevated mitochondrial lipid peroxidation and mitochondrial dysfunction. Brain 2015; 138: 1801-1816.

Sofola-Adesakin O, Castillo-Quan JI, Rallis C, Tain L, Bjedov I, Rogers I, Martínez P, Khericha M, Cabecinha M, Bähler J & Partridge L. Lithium suppresses Aβ pathology by inhibiting translation in an adult Drosophila model of Alzheimer’s disease. Front Aging Neurosci 2014; 6:190.

Castillo-Quan JI, Kinghorn KJ. Molecular Gerontology: towards healthy ageing. Gac Med Mex 2013; 149:680-5. (In Spanish)

Castillo-Quan JI. From white to brown fat through the PGC-1α-dependent myokine irisin: implications for diabetes and obesity. Dis Model Mech 2012; 5:293-5.

Castillo-Quan JI. Parkin’ control: regulation of PGC-1α through PARIS in Parkinson’s disease. Dis Model Mech 2011; 4:427-9.

Castillo-Quan JI, Barrera-Buenfil DJ, Pérez-Osorio JM, Alvarez-Cervera FJ. Depression and Diabetes: from epidemiology to neurobiology. Rev Neurol 2010; 51: 347-59. (In Spanish & English)

Castillo Quan JI. Rosiglitazone effects to ameliorate Alzheimer’s disease pathogenic features: focusing in the insulin signaling and neurotrophic factors. J Neuropsychiatry Clin Neurosci 2009; 21: 347-8.

Castillo-Quan JI. Pérez-Osorio JM. The MTHFR gene in Alzheimer’s disease: a potential nutrigenomic approach for Mexico. Gac Med Méx 2009; 145: 147-50. (In Spanish)

Castillo-Quan JI, Barrera-Buenfil DJ, Pérez-Osorio JM. The role of insulin and cortisol on memory and Alzheimer’s disease pathology: implications for Diabetes. Cambridge Medicine 2008; 22: 31-35.

Xacur-Garcia F, Castillo-Quan JI, Laviada-Molina H, Hernandez-Escalante V. Nutritional genomics: a genome-environment interaction. Rev Med Chil 2008; 136: 1460-7. (In Spanish)

Castillo-Quan JI. Insulin resistance, hypercortisolism, polycystic ovarian syndrome, and depression ­­‑ nonrandom associations? Fert Steril 2008; 89: 1029-30.

Castillo-Quan JI, Herrera-González A, Pérez-Osorio JM. Insulin-cortisol interaction in depression and other neurological diseases: an alternative hypothesis. Psychoneuroendocrinology 2007; 32: 854-855.

Castillo-Quan JI. Pérez-Osorio JM. Cortisol secretion in patients with type 2 diabetes: relationship with chronic complications (Letter). Diabetes Care 2007; 30: e49.